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U-PHARM
Laboratories LLC
Laboratories LLC
Accelerate drug discovery
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Select Publications of Our Members
Zhong H, Sánchez, C, Caron, MG. Consideration of allosterism and interacting proteins in the
physiological functions of the serotonin transporter. (2012) Biochem Pharmacol, 83(4):435-42. Epub
2011 Oct 1. (Review)
Zhong H, Haddjeri N, Sánchez C. (2012) Escitalopram, an antidepressant with an allosteric effect at
the serotonin transporter-a review of current understanding of its mechanism of action.
Psychopharmacology (Berl). 219(1):1-13. Epub 2011 Sep 8. (Review)
Hao, W., Chang, B.C., Tsao, C., Xu, J. (2010) Oligomycin-induced bioenergetic adaptation in cancer
cells with heterogeneous bioenergetics organizations. J Biol Chem 285: 12647-12654
Zhong H, Hansen KB, Boyle NJ, Han K, Muske G, Huang X, Egebjerg J, Sánchez C. (2009) An
allosteric binding site at the human serotonin transporter mediates the inhibition of escitalopram by
R-citalopram: kinetic binding studies with the ALI/VFL-SI/TT mutant. Neurosci Lett. 462(3):207-12.
Walker MW, Wolinsky TD, Jubian V, Chandrasena G, Zhong H, Huang X, Miller S, Hegde LG,
Marsteller DA, Marzabadi MR, Papp M, Overstreet DH, Gerald CP, Craig DA. (2009) The novel
neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-
d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and
antidepressant-like effects in rat models of stress sensitivity. J Pharmacol Exp Ther. 328(3):900-11.
Hao, W, Hu, Y.,Liu, C., Huang, X., Chang, B.C., Gibbons, J., Xu, J. (2008) Discovery of the
catechol-containing compound as a Stat3 SH2 domain inhibitor by virtual screening. Bioorgan Med
Chem Lett. 18: 4988-4992
Xu, J., Ayyad, R., Chang, B.C., Asselin, M., Hao, W., Gibbons, J., Cole, D.C., Park, K. (2008) Inhibition
of the Stat3 singaling pathway by 4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxylic acid ethyl
esters. J Med Chem. 51: 4115-4121
Titus SA, Li X, Southall N, Lu J, Inglese J, Brasch M, Austin CP, Zheng W. (2008) A Cell-based PDE4
Assay in 1536-well plate format for High Throughput Screening. J Biomol Screen. 13(7):609-18.
David DJ, Klemenhagen KC, Holick KA, Saxe MD, Mendez I, Santarelli L, Craig DA, Zhong H, Swanson
CJ, Hegde LG, Ping XI, Dong D, Marzabadi MR, Gerald CP, Hen R. (2007) Efficacy of the MCHR1
antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-
2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute
and chronic administration is independent of hippocampal neurogenesis. J Pharmacol Exp Ther.
321(1):237-48.
Maloney, K.N., Hao, W., Xu, J., Gibbons, J., Hucul, J., Roll, D., Brady, S.F., Schroeder, F.C., Clardy, J.
(2006) Phaeosphaeride A, a selective inhibitor of STAT3-dependent signaling isolated from an
endophytic fungus. Org. Lett., 8: 4067 -4070
Tang Y, Li X, He J, Lu J, Diwu Z. (2006) Real-time and high throughput monitoring of cAMP in live
cells using a fluorescent membrane potential-sensitive dye. Assay Drug Dev Technol. 4(4):461-71.
Swanson CJ, Blackburn TP, Zhang X, Zheng K, Xu ZQ, Hokfelt T, Wolinsky TD, Konkel MJ, Chen H,
Zhong H, Walker MW, Craig DA, Gerald CP, Branchek TA. (2005) Anxiolytic- and antidepressant-like
profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299. Proc Natl Acad
Sci U S A. 102(48):17489-94.
Martin MB, Voeller HJ, Gelmann EP, Lu J, Stoica EG, Hebert EJ, Reiter R, Singh B, Danielsen M,
Pentecost E, Stoica A. (2002) Role of cadmium in the regulation of AR gene expression and activity.
Endocrinology. 143(1):263-75.
Ung T.L., Cao C., Lu J., Ozato K., Dever T.E. (2001) Heterologous dimerization domains functionally
substitute for the double-stranded RNA binding domains of the kinase PKR. EMBO J. 20(14):3728-37.
Zhong H and Neubig RR. (2001) RGS Proteins: Novel Multifunctional Drug Targets. J. Pharmcol. Exp.
Ther. 297: 837-45. (Cover Review).
physiological functions of the serotonin transporter. (2012) Biochem Pharmacol, 83(4):435-42. Epub
2011 Oct 1. (Review)
Zhong H, Haddjeri N, Sánchez C. (2012) Escitalopram, an antidepressant with an allosteric effect at
the serotonin transporter-a review of current understanding of its mechanism of action.
Psychopharmacology (Berl). 219(1):1-13. Epub 2011 Sep 8. (Review)
Hao, W., Chang, B.C., Tsao, C., Xu, J. (2010) Oligomycin-induced bioenergetic adaptation in cancer
cells with heterogeneous bioenergetics organizations. J Biol Chem 285: 12647-12654
Zhong H, Hansen KB, Boyle NJ, Han K, Muske G, Huang X, Egebjerg J, Sánchez C. (2009) An
allosteric binding site at the human serotonin transporter mediates the inhibition of escitalopram by
R-citalopram: kinetic binding studies with the ALI/VFL-SI/TT mutant. Neurosci Lett. 462(3):207-12.
Walker MW, Wolinsky TD, Jubian V, Chandrasena G, Zhong H, Huang X, Miller S, Hegde LG,
Marsteller DA, Marzabadi MR, Papp M, Overstreet DH, Gerald CP, Craig DA. (2009) The novel
neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-
d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and
antidepressant-like effects in rat models of stress sensitivity. J Pharmacol Exp Ther. 328(3):900-11.
Hao, W, Hu, Y.,Liu, C., Huang, X., Chang, B.C., Gibbons, J., Xu, J. (2008) Discovery of the
catechol-containing compound as a Stat3 SH2 domain inhibitor by virtual screening. Bioorgan Med
Chem Lett. 18: 4988-4992
Xu, J., Ayyad, R., Chang, B.C., Asselin, M., Hao, W., Gibbons, J., Cole, D.C., Park, K. (2008) Inhibition
of the Stat3 singaling pathway by 4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxylic acid ethyl
esters. J Med Chem. 51: 4115-4121
Titus SA, Li X, Southall N, Lu J, Inglese J, Brasch M, Austin CP, Zheng W. (2008) A Cell-based PDE4
Assay in 1536-well plate format for High Throughput Screening. J Biomol Screen. 13(7):609-18.
David DJ, Klemenhagen KC, Holick KA, Saxe MD, Mendez I, Santarelli L, Craig DA, Zhong H, Swanson
CJ, Hegde LG, Ping XI, Dong D, Marzabadi MR, Gerald CP, Hen R. (2007) Efficacy of the MCHR1
antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-
2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute
and chronic administration is independent of hippocampal neurogenesis. J Pharmacol Exp Ther.
321(1):237-48.
Maloney, K.N., Hao, W., Xu, J., Gibbons, J., Hucul, J., Roll, D., Brady, S.F., Schroeder, F.C., Clardy, J.
(2006) Phaeosphaeride A, a selective inhibitor of STAT3-dependent signaling isolated from an
endophytic fungus. Org. Lett., 8: 4067 -4070
Tang Y, Li X, He J, Lu J, Diwu Z. (2006) Real-time and high throughput monitoring of cAMP in live
cells using a fluorescent membrane potential-sensitive dye. Assay Drug Dev Technol. 4(4):461-71.
Swanson CJ, Blackburn TP, Zhang X, Zheng K, Xu ZQ, Hokfelt T, Wolinsky TD, Konkel MJ, Chen H,
Zhong H, Walker MW, Craig DA, Gerald CP, Branchek TA. (2005) Anxiolytic- and antidepressant-like
profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299. Proc Natl Acad
Sci U S A. 102(48):17489-94.
Martin MB, Voeller HJ, Gelmann EP, Lu J, Stoica EG, Hebert EJ, Reiter R, Singh B, Danielsen M,
Pentecost E, Stoica A. (2002) Role of cadmium in the regulation of AR gene expression and activity.
Endocrinology. 143(1):263-75.
Ung T.L., Cao C., Lu J., Ozato K., Dever T.E. (2001) Heterologous dimerization domains functionally
substitute for the double-stranded RNA binding domains of the kinase PKR. EMBO J. 20(14):3728-37.
Zhong H and Neubig RR. (2001) RGS Proteins: Novel Multifunctional Drug Targets. J. Pharmcol. Exp.
Ther. 297: 837-45. (Cover Review).
